Kinetics of Leptin Binding to the Q223R Leptin Receptor
نویسندگان
چکیده
منابع مشابه
Kinetics of Leptin Binding to the Q223R Leptin Receptor
Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant. We set out to determine whether the Q223R substitution affects leptin binding kinetic...
متن کاملEffect of leptin receptor Q223R polymorphism on breast cancer risk
Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...
متن کاملFunctional consequences of the human leptin receptor (LEPR) Q223R transversion.
Perturbations in the functional integrity of the leptin axis are obvious candidates for mediation of altered adiposity. In a large number of genetic association studies in humans, the nonconservative LEPR Q223R allele has been inconsistently associated with adiposity. Subtle, long-term effects of such genetic variants can be obscured by effects of the environment and other confounders that rend...
متن کاملEffect of leptin receptor Q223R polymorphism on breast cancer risk
OBJECTIVES Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. MATERIALS AND METHODS We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...
متن کاملeffect of leptin receptor q223r polymorphism on breast cancer risk
objective(s):leptin receptor (lepr) is a member of the class i cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. we have investigated the effect of q223r polymorphism on the breast cancer susceptibly in a sample of iranian subjects. materials and methods:we utilized a polymerase chain reaction (pcr) restriction fragment length polymorphi...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0094843